Immune Response to Chlamydia

Host Immune Response to Chlamydia Infection

1. protection against intracellular bacteria is mediated by T cells, which are interacting, not directly with the pathogen, but with the infected cell surface; antibodies exhibit a minor effect on the immune protection against intracellular infections; 2. infections by intracellular bacteria is accompanied by delayed hypersensitivity reactions that occur after the local administration of solubl...

Antibody response to chlamydia agents: lack of immunoglobulin M antibodies during the secondary immune response.

Intramuscular inoculation of the monkey with a massive dose of Chlamydia agent particles resulted in the production of high levels of immunoglobulin M antibodies. These antibodies were broadly specific and reacted to high titers with heterologous antigens. Challenge inoculation of the same monkeys with heterologous Chlamydia agent particles resulted in the production of increased levels of immu...

Immune Response in Infected Epithelial Impairs the Innate Chlamydia pneumoniae

Cell-mediated immune response during primary Chlamydia pneumoniae infection.

The development of Chlamydia pneumoniae-specific cell-mediated immunity was studied during a primary C. pneumoniae infection. The immune response was detected as positive lymphocyte proliferation and secretion of interferon gamma. C. pneumoniae-induced activation of both CD4(+) and CD8(+) T cells was detected in the early phase of infection, but activation of only CD4(+) T cells was detected in...

Host immune response to Chlamydia pneumoniae heat shock protein 60 is associated with asthma.

Chlamydia pneumoniae infection has been associated with asthma. It has also been suggested that heat shock protein 60 (Hsp60) belonging to a class of highly conserved proteins may play a role in the pathogenesis of chlamydial infections. The purpose was to study whether the host immune response to C. pneumoniae Hsp60 is associated with asthma and decreased pulmonary function. An enzyme immunoas...